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Granulation Equipment
Granulation, the process of particle enlargement by agglomeration technique, is one of the most significant unit operations in the production of pharmaceutical dosage forms, mostly tablets and capsules. Granulation process transforms fine powders into free-flowing, dust-free granules that are easy to compress.
High Shear Granulators
The key to success is the unique design of vessel and mixing tools. The angled position of the mixing blades combined with the rounded edges at the bottom of the vessel guarantee the typical rope-type movement for optimal flow of product during granulation. Several binder liquid spray systems are available to suit your process. Bowl and mixing blades are shaped and mounted to minimize clearance for maximum yield, without locally overheating the product. During a discharge cycle, the centrifugal force created by the rotation of the mixing arm will push the product in a natural way to a proportionally regulated outlet valve at the side without compacting the wet granules. This way we can accurately dose the finished granules to a calibration unit, connected to the outlet.
High Shear Granulators
- User-friendly operation
- Cleanibility, safety and maintenance
High Shear Processor
A multi-purpose processor that's equally suitable for the high speed dispersion of dry powders, aqueous or solvent granulations, effervescent production and wet or melt pelletization for Pharma applications. What ever the subsequent production steps, the formulation of an active compound and other excipients needs to be mixed homogeneously. Low shear mixing relies on the planetary movement of the mixer arm to achieve homogeneity, while high shear mixing uses a high intensity mixing blade resulting in a homogeneous blend. Which technique is most suitable depends on the subsequent production step. We can assist in making the right choice. To form granules out of powders a granulation liquid and mechanical energy is needed. The formation of pellets can be considered as granulation taken one step further, to achieve spherical granules. For high shear pelletization, a special mixing tool is available to optimize the process and maximise the output.
High Shear Processor
- Process containment
- Impeller and chopper options.
- Available as standalone or through-the-wall installations
- Integrated WIP or CIP
- Modular upgrades are available for future requirements
- Full opening cover for easy inspection
- Latest endpoint detection techniques
- Advanced process control for repeatability
- Complete ease of operation (fully automated or manual)
Single Pot Processors
A single pot processor is a high-shear mixer-granulator that is also equipped with drying technologies. Thus, single pot processing is the production of pharmaceutical granules using a wet granulation process in which dry mixing, liquid addition, wet granulation, drying and sizing of the granules is done in one machine. Single Pot Processors (One-Pot Processor) offer a choice of mixing, granulation and drying options integrated into one processing vessel. With our help, choose the most appropriate technique for your product. With the high-shear granulation technology as the basis, Single Pot Processing relies on the application of a vacuum within the bowl to dry the wet mass. This technique allows drying of pharmaceutical compounds at low temperature, and for minimal environmental exhaust through very efficient solvent recovery, even if organic solvents are used for granulation. The vacuum drying process can be enhanced by the Transflo technique or microwave drying.
Single Pot Processors
- By integrating granulating and drying capabilities into a single unit, capital investment in equipment and good manufacturing practice (GMP) floor space is lower than other alternatives.
- The number of material handling steps is decreased: consequently, the total processing time is shorter while maintaining a high yield and keeping production support to a minimum. At the same time also the number of required operators is reduced.
- Environmental variables, such as humidity, are eliminated from the manufacturing process, which may offer advantages for processing moisture-sensitive formulations.
- Requirements for solvent recovery systems are lower for single-pot processors compared with fluid bed dryers.
- Reaching a high level of containment is easy by application of the correct measures at in- and outlet valves.
- A single pot can be changed over in less than 2 hours, which makes it a very attractive technology if a large number of different products- demanding a high number of product changeovers- has to be produced.